Population
Mice with isoproterenol-induced cardiac hypertrophy and mice with exercise-induced physiological…
Comparison
Isoproterenol-induced cardiac hypertrophy vs Exercise-induced physiological hypertrophy…
Design
Preclinical
Authors
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Rodent hypertrophy gene signatures should not guide HF care; leaves open their causal role or biomarker utility in humans.
The isoproterenol-induced cardiomyopathy model shares a canonical set of 64 altered genes with human failing hearts, with ischemia being the human condition most resembling isoproterenol treatment at the transcriptional level.
Galindo et al. (2009) studied this question.
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