The in vitro lymphocyte response to phytohemagglutinin (PHA) was studied in 44 patients with bronchogenic carcinoma. The PHA responses of these patients varied greatly, with a mean which was significantly depressed as compared to that of normal individuals (p < 0.001). The lymphocyte response to PHA was markedly impaired in most patients with inoperable (late stage) disease, as compared to those with resectable tumors (p < 0.05). There may be a correlation between lymphocyte reactivity and survival with bronchogenic carcinoma.
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Han et al. (1972) studied this question.
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