Why the study?
Does intravenous trypsin produce a significant fibrinolytic effect on radioactive thrombi and emboli in vivo?
Does intravenous trypsin produce a significant fibrinolytic effect on radioactive thrombi and emboli in vivo?
Using a novel quantitative method with I 131 labeled fibrinogen, intravenous trypsin was found to have no significant in vivo fibrinolytic effect.
Answers are grounded in this paper and cite their sources.
Does not support trypsin for fibrinolysis; leaves open whether other agents merit testing in preclinical thrombosis models.
Quantitative methods for testing fibrinolytic agents in vivo are described. Methods based on the incorporation into the clot of P 32 labeled blood cells or Cr 51 labeled erythrocytes were found to be unsatisfactory. Clots were produced with I 131 labeled fibrinogen. Dissolution of a clot resulted in decrease of radioactivity. This was recorded by placing segments of blood vessels in a special lead shield containing a scintillation detector head, connected to a radiation rate meter and an Esterline recorder. Pulmonary, peripheral and coronary emboli were produced by injecting radioactive clots produced and ground, in vitro. Using these methods it was found that maximal tolerated doses of trypsin showed no significant fibrinolytic effect.
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Ambrus et al. (1956) studied this question.
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