Population
Guinea pig atrial muscle
Comparison
Caffeine (3mM to 50mM) vs Normal Krebs solution, sodium-free Tris-maleate…
Design
Preclinical
Authors
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Hypothesis-generating in isolated animal tissue; leaves open relevance to human myocardial calcium handling or therapy.
Caffeine augments myocardial contraction by acting on both the surface membrane and sarcoplasmic reticulum to enhance inward calcium movement.
Yosiko KIMOTO (1972) studied this question.
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