Why the study?
EV71 is transmitted by the enteral route, but little is known about the mechanisms it uses to cross the human gastrointestinal tract.
Population
Primary human intestinal epithelial monolayers
Comparison
EV71 infection vs uninfected control
Design
In vitro laboratory study
Authors
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Supports goblet cell targeting to block EV71 entry; leaves open in vivo and clinical validation.
Type III interferon signaling restricts enterovirus 71 replication in human intestinal epithelial goblet cells.
Good et al. (2019) studied this question.
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