Why the study?
Does suppressing TMAO with DMB mitigate vascular dysfunction, exercise intolerance, and frailty in mice on a Western-style diet?
Does suppressing TMAO with DMB mitigate vascular dysfunction, exercise intolerance, and frailty in mice on a Western-style diet?
Suppressing the gut microbiome-derived metabolite TMAO with DMB mitigates diet-induced vascular dysfunction and frailty in mice, identifying a potential therapeutic target for human translation.
Hypothesis-generating for TMAO suppression in diet-related vascular dysfunction; human trials needed before clinical consideration.
We provide novel evidence that increased circulating concentrations of the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) contribute to vascular dysfunction associated with consumption of a Western-style diet and that this dysfunction can be prevented by suppressing TMAO with DMB, thereby supporting translation of this compound to humans. Furthermore, to our knowledge, we present the first evidence of the role of TMAO in mediating impairments in endurance exercise tolerance and increased frailty in any context.
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Brunt et al. (2022) studied this question.
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