April 1, 2008Obstetrical & Gynecological Survey
Factors Associated With 5-Year Risk of Hip Fracture in Postmenopausal Women
Why the study?
Does a clinical feature-based algorithm accurately predict the 5-year risk of hip fracture in postmenopausal women compared to DXA scans?
Population
161,808 postmenopausal women from the Women's Health Initiative in the United States, including 93,676 in…
Comparison
Predictive algorithm for 5-year hip fracture… vs Dual-energy x-ray absorptiometry scan predictions
Design
Cohort
Follow-up
average 7.6 years and 8.0 years
Authors
Discussion
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Member takes
Implication
Clinical algorithm matches DXA accuracy for hip fracture prediction; hypothesis-generating before replacing bone density testing.
Structured PICO
Does a clinical feature-based algorithm accurately predict the 5-year risk of hip fracture in postmenopausal women compared to DXA scans?
P
Population
161,808 postmenopausal women from the Women's Health Initiative in the United States, including 93,676 in the observational derivation cohort, 68,132 in the clinical trial validation cohort, and a subset of 10,750 with DXA measurements.
I
Intervention
Predictive algorithm for 5-year hip fracture risk based on 11 clinical features (age, self-reported health, body weight, height, race/ethnicity, self-reported physical activity, history of fracture after age 54 years, hip fracture in a parent, current smoking, current steroid use, and treated diabetes)
C
Comparator
Dual-energy x-ray absorptiometry (DXA) scan predictions
O
Outcome
5-year risk of hip fracturehard clinical
A predictive algorithm based on readily available clinical features can accurately predict the 5-year risk of hip fracture in postmenopausal women, performing comparably to DXA scans.
Cite This Study
Robbins et al. (2008) studied this question.