Adverse drug reactions: back to the future

Q: What is the clinical evidence from this study?

Study design: Review. Population: Adverse drug reactions. Intervention: Pharmacotherapy and pharmacovigilance. Primary outcome: Hospital admissions and mortality due to adverse drug reactions.

Q: What does this research mean for the field?

Adverse drug reactions account for approximately 7% of all hospital admissions and 4% of UK hospital-bed days, with approximately 10% of newly approved drugs in the US either withdrawn or receiving Black Box warnings over 25 years. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Munir Pirmohamed; B. Kevin Park

doi:10.1046/j.1365-2125.2003.01847.x

May 1, 2003British Journal of Clinical PharmacologyOpen Access

Adverse drug reactions: back to the future

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Key result

Adverse drug reactions account for ~7% of all hospital admissions.

or 7

PICO

P

Population

Adverse drug reactions

E

Exposure / Comparator

Pharmacotherapy and pharmacovigilance

O

Primary Outcome

Hospital admissions and mortality due to adverse drug reactions

Limitations

Spontaneous reporting schemes such as the yellow card system suffer from a high degree of under-reporting.
Limited statistical power at drug licensing (only ~1500 patients exposed) to detect rare Type B adverse drug reactions.
Lack of resources has slowed the uptake of computerized prescribing systems that could prospectively identify errors.

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Cite This Study

Pirmohamed et al. (2003) conducted a review in Adverse drug reactions. Pharmacotherapy and pharmacovigilance was evaluated on Hospital admissions and mortality due to adverse drug reactions. Adverse drug reactions account for 7% of all hospital admissions and 4% of UK hospital-bed days, with 10% of new US drugs withdrawn or given Black Box warnings over 25 years.

synapsesocial.com/papers/6a72f999c5a6515d7e9a2f85 https://doi.org/10.1046/j.1365-2125.2003.01847.x

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Adverse drug reactions: back to the future

PICO

Limitations

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Abstract

Discussion

Cite This Study

Adverse drug reactions: back to the future

PICO

Limitations

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Abstract

Discussion

Cite This Study

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