Why the study?
Does CSF delivery of AAV9 improve CNS transduction compared to intravascular delivery in nonhuman primates?
Does CSF delivery of AAV9 improve CNS transduction compared to intravascular delivery in nonhuman primates?
CSF delivery of AAV9 in nonhuman primates yields greater CNS transduction than intravascular delivery, but neither route shields against preexisting anti-AAV antibodies.
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CSF AAV9 delivery may boost primate CNS transduction over IV routes; leaves open human translation pending antibody mitigation and safety trials.
Samaranch et al. (2011) studied this question.
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