Why the study?
Inflammation, fibrosis, and metabolic stress promote HFpEF, and profiling interstitial cells was needed to identify disease-specific traits during adverse remodeling.
Population
Murine HFpEF model (high-fat diet and L-NAME), two HFrEF mouse models, and HFpEF patient plasma samples
Comparison
Early HFpEF vs HFrEF murine models
Design
Preclinical single-cell RNA sequencing and translational validation study
Authors
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Highlights interstitial cell states for HFpEF modeling; leaves open human validation and therapeutic targeting.
Single-cell transcriptomics reveals distinct fibroblast activation patterns in HFpEF compared to HFrEF, identifying Angiopoietin-like 4 as a potential biomarker for disease progression.
Lanzer et al. (2023) studied this question.
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