Does polylaminin manipulate titin isoform shift and phosphorylation in cardiomyocytes to alleviate HFpEF symptoms?
Polylaminin is proposed as a novel therapeutic strategy to address elevated passive myocardial stiffness in HFpEF by targeting titin modifications.
No effective medical treatment exists for heart failure with preserved ejection fraction (HFpEF), accounting for approximately half of all heart failure cases. The elevated passive myocardial stiffness in HFpEF is attributed to a combination of alterations in the extracellular matrix (ECM) collagen content and modifications in the sarcomeric protein titin. Here, we propose polylaminin, a biomimetic polymer of laminin, as a promising approach for manipulating the titin isoform shift and phosphorylation in cardiomyocytes. Exploring the pleiotropic effects of polylaminin may be a novel strategy for alleviating symptoms in HFpEF's multifactorial pathophysiology.
Hochman‐Mendez et al. (Fri,) studied this question.