What question did this study set out to answer?

To examine how selectively targeting extracellular matrix components can attenuate progressive cardiac fibrosis and pathological ventricular remodeling following myocardial infarction.

November 1, 2018Annals of Translational MedicineOpen Access

Targeting selected extracellular matrix components to attenuate cardiac fibrosis

View Full Paper

Ask AI

Bookmark

To examine how selectively targeting extracellular matrix components can attenuate progressive cardiac fibrosis and pathological ventricular remodeling following myocardial infarction.
Synthesized evidence on post-ischemic structural remodeling and extracellular matrix dynamics in infarcted myocardial tissue.
Assessed molecular targets within the extracellular matrix capable of modulating adverse fibrotic responses after ischemic injury.
Pathological extracellular matrix remodeling following ischemic damage was identified as a primary mechanism promoting heart failure progression.
Selective molecular targeting of matrix components shows therapeutic promise for mitigating maladaptive cardiac remodeling and preserving ventricular function.

Design

Review

Implication

Supports ECM-targeted approaches in post-MI remodeling; leaves open clinical efficacy in human heart failure.

Abstract

Progressive fibrosis is a hallmark of heart failure and remains a central challenge in managing patients who have suffered from myocardial infarction (MI). Following ischemic injury to the heart, structural remodeling of the infarcted myocardium ensues.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Pattar et al. (2018) studied this question.

synapsesocial.com/papers/6a71a219ac440176ef2a4245 https://doi.org/10.21037/atm.2018.10.02

View Full Paper

Ask AI

Bookmark

Implication

Supports ECM-targeted approaches in post-MI remodeling; leaves open clinical efficacy in human heart failure.

Targeting selected extracellular matrix components to attenuate cardiac fibrosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Targeting selected extracellular matrix components to attenuate cardiac fibrosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading