Research progress and prospect on the mechanism of extracellular matrix remodeling based on myocardial cells

Cardiovascular disease is the most lethal disease in all kinds of diseases in the world, and it has important global public health significance for its prevention and treatment. Myocardial fibrosis is one of the typical pathological manifestations of cardiovascular disease, which seriously affects the diastolic and systolic function of the ventricle and ultimately leads to heart failure. The matrix of cells surrounding cardiomyocytes has an important role in controlling cell proliferation, differentiating, and preserving the structural and functional integrity of the heart. The predominant factor contributing to myocardial fibrosis is the dysregulation of collagen homeostasis within the cardiomyocyte extracellular matrix. Therefore, preventing and reversing myocardial extracellular matrix remodeling has become an important goal for improving cardiac dysfunction and treating cardiovascular diseases. Modern studies have found that its reconstruction is often related to the expression of multiple pathways and the regulation of related factors. Based on this, together with the advancements in traditional Chinese and Western medical treatment, new concepts for enhancing cardiac function and patient quality of life are predicted to emerge.