Key result
Activated matrix proteinases and their endogenous inhibitors drive extracellular matrix remodeling, leading to ventricular dilatation and myocardial dysfunction in ischemic heart disease.
This review summarizes the molecular and cellular mechanisms of extracellular matrix remodeling in heart failure, highlighting matrix metalloproteinases as potential pharmacological targets.
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May identify matrix metalloproteinases as targets to limit remodeling; leaves open validation in prospective trials.
Suresh C. Tyagi (1997) conducted a review in Heart failure, ischemic heart disease, dilated cardiomyopathy. Extracellular matrix remodeling and matrix proteinases was evaluated. Activated matrix proteinases and their endogenous inhibitors drive extracellular matrix remodeling, leading to ventricular dilatation and myocardial dysfunction in ischemic heart disease.
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