Population
Rat model of myocardial infarction
Comparison
Ligation of the left anterior descending… vs Non-infarcted tissue controls or same regions in…
Design
Preclinical
Follow-up
1-3 hours
Authors
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Rapid collagen degradation in animal MI models is hypothesis-generating; leaves open human timing and therapeutic relevance.
Myocardial infarction induces rapid degradation of extracellular matrix collagen within 1-3 hours, likely driven by increased collagenase and neutral proteinase activities.
Takahashi et al. (1990) studied this question.
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