Key result
In an experimental rabbit model, the acutely infarcted ventricle was highly resistant to rupture during the initial 48 hours post-MI, after which collagen synthesis determined infarct stiffness.
Population
54 rabbits (36 with experimental myocardial infarction via coronary ligation, 18 shams)
Comparison
Experimental myocardial infarction via coronary… vs Sham operation
Design
Preclinical
Follow-up
8 days
Authors
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May guide timing of post-MI rupture prevention strategies; leaves open clinical translation from rabbit models.
Preinfarction collagen content prevents early post-MI rupture, while subsequent collagen synthesis determines infarct stiffness and resistance to rupture after 72 hours.
Lerman et al. (1983) studied Acute myocardial infarction (n=54). Coronary ligation (experimental infarction) vs. Sham operation was evaluated on Collagen formation and mechanical resistance of the infarcted left ventricle to stretch and rupture. In an experimental rabbit model, the acutely infarcted ventricle was highly resistant to rupture during the initial 48 hours post-MI, after which collagen synthesis determined infarct stiffness.