Key result
Canine MI reduces LV rupture threshold by ~35% versus noninfarcted hearts.
Population
70 dogs
Comparison
Myocardial infarction induced by left anterior… vs Noninfarcted hearts
Design
Preclinical
Follow-up
1-42 days (6 weeks)
Authors
Loading...
May signal late mechanical vulnerability after canine MI; hypothesis-generating for human postinfarct rupture risk and remodeling studies.
Absolute Event Rate: 754% vs 1168%
p-value: p=<0.001
In a canine model of myocardial infarction, the left ventricular rupture threshold and prerupture stiffness decrease late in the healing phase, suggesting a late decrease in mechanical strength and resistance to distension.
Bodh I. Jugdutt (1987) studied Myocardial infarction (n=70). Left anterior descending coronary artery ligation (Myocardial infarction) vs. Noninfarcted hearts (sham or no ligation) was evaluated on Left ventricular rupture threshold (p=<0.001). Myocardial infarction in dogs significantly decreased the left ventricular rupture threshold compared to noninfarcted hearts (754 vs 1168 mmHg, p<0.001), with a further decrease after 14 days.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: