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January 1, 2002˜The œNephron journals/Nephron journals

Heminephrectomy Causes the Progression of Glomerulosclerosis and Apoptosis in High IgA Strain ddY Mice

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Population

Five-week-old high immunoglobulin A inbred strain of ddY mice (HIGA mice)

Comparison

Heminephrectomy vs Sham operation

Design

Preclinical

Follow-up

35 weeks

Authors

HKHitoshi KusanoNEC (Japan)EMEri MusoKyoto Kacho UniversityTOTakahiko OnoHyogo Prefectural Amagasaki General Medical Center

Discussion

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Implication

Establishes heminephrectomy in HIGA mice as a glomerulosclerosis model; leaves open translation to human IgA nephropathy.

Structured PICO

P
Population
Five-week-old high immunoglobulin A inbred strain of ddY mice (HIGA mice)
I
Intervention
Heminephrectomy
C
Comparator
Sham operation
O
Outcome
Histological findings, immunoglobulin depositions, expressions of cytokine and extracellular matrix proteins, apoptosis, and tissue renin-angiotensin systemssurrogate

Heminephrectomy in HIGA mice accelerates progressive glomerulosclerosis and apoptosis, potentially serving as a model for human IgA nephropathy.

Cite This Study

Kusano et al. (2002) studied this question.

synapsesocial.com/papers/6a72fbb764272606b331e336https://doi.org/10.1159/000063321
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  1. 1Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.1994 · 1,086 citations
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  3. 3Epidemiology of IgA nephropathy in central and eastern Kentucky for the period 1975 through 1994. Central Kentucky Region of the Southeastern United States IgA Nephropathy DATABANK Project.1998 · 105 citations