Why the study?
Does the chemical structure of sympathomimetic amines determine their ability to produce ventricular tachycardia in dogs during cyclopropane anesthesia?
Does the chemical structure of sympathomimetic amines determine their ability to produce ventricular tachycardia in dogs during cyclopropane anesthesia?
Primary and secondary sympathomimetic amines with a catechol nucleus consistently induce ventricular tachycardia in dogs under cyclopropane anesthesia, unlike tertiary or non-catechol amines.
Certain amine structures may heighten arrhythmia risk under specific anesthesia in models; leaves open translation to current clinical practice.
Fifteen additional sympathomimetic amines have been tested for their ability to produce ventricular tachycardia in the dog during cyclopropane anesthesia. In a dosage producing a blood pressure rise equal to that caused by 0.01 mgm. of adrenalin per kilogram, the six primary and secondary amines with a catechol nucleus consistently elicited ventricular tachycardia. Tertiary amines with a catechol nucleus and the other amines used did not cause this irregularity.
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Orth et al. (1945) studied this question.
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