Key result
Natural, plant-derived antioxidants may play a cardioprotective role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity driven by oxidative and nitrative stress.
Why the study?
Cardiotoxicity is a dose-limiting factor during cyclophosphamide therapy thought to encompass oxidative and nitrative stress, prompting interest in cardioprotective antioxidants.
Do antioxidants prevent or ameliorate cyclophosphamide-induced cardiotoxicity?
Do antioxidants prevent or ameliorate cyclophosphamide-induced cardiotoxicity?
This review highlights the potential of natural, plant-derived antioxidants in mitigating cyclophosphamide-induced cardiotoxicity.
Hypothesis-generating for plant antioxidant adjuncts with cyclophosphamide; leaves open clinical adoption pending randomized trials.
The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously been shown to induce complications within the setting of bone marrow transplantation. More recently, cardiotoxicity has been shown to be a dose-limiting factor during cyclophosphamide therapy, and cardiooncology is getting wider attention. Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress. As such, this review focuses on antioxidants and their role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity. It will give special emphasis to the cardioprotective effects of natural, plant-derived antioxidants that have garnered significant interest in recent times.
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Ayza et al. (2020) conducted a review in Cyclophosphamide-induced cardiotoxicity. Antioxidants was evaluated. Natural, plant-derived antioxidants may play a cardioprotective role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity driven by oxidative and nitrative stress.
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