A Laboratory and Field Evaluation of Amprolium—A New Anticoccidial

THE list of anticoccidial drugs is steadily increasing as more perfected means are developed for the control of coccidian infections in domestic birds and other farm animals. One of the most recent of these is Amprolium.2 Literature references are few. Cuckler, Garzillo, Malanga and McManus (1960) found the drug to be highly effective under laboratory conditons against infections with Eimeria tenella and necatrix, but less effective against E. acervulina, maxima and brunetti. Ott, Dickinson and Van Iderstine (1960) report Amprolium to be well tolerated when administered in the mash to chickens at feed concentrations up to 0.05 percent. Adverse effects noted at intakes in excess of 0.1 percent were overcome by the supplemental administration of thiamine indicating Amprolium to be a thiamine antagonist. Polis (1960) found the drug to have no adverse effects upon any phase of the reproductive cycle in chickens when administered in the feed up to 0.1 …