Population
Striated muscle myofilaments regulated by cardiac TnC, skeletal TnC, and CaM, including myofibrillar…
Comparison
Calmidazolium (CDZ) (e.g., 10 microM) vs Control (absence of CDZ)
Design
Preclinical
Authors
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Calmidazolium may sensitize myofilaments to Ca2+ in vitro; hypothesis-generating for calcium sensitization, no clinical implications yet.
Calmidazolium sensitizes cardiac myofilaments to calcium activation, demonstrating that the effects of calcium-binding protein antagonists depend on the specific protein-protein interactions and environment.
El-Saleh et al. (1987) studied this question.
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