What question did this study set out to answer?

To isolate and characterize novel bromotyrosine derivatives from the marine sponge Pseudoceratina purpurea and evaluate their inhibitory effects against histone deacetylase and DNA methyltransferase.

April 18, 2003The Journal of Organic Chemistry

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

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To isolate and characterize novel bromotyrosine derivatives from the marine sponge Pseudoceratina purpurea and evaluate their inhibitory effects against histone deacetylase and DNA methyltransferase.
Extracted and isolated six new bromotyrosine derivatives (psammaplins E–J) alongside known psammaplins A–D and bisaprasin from Pseudoceratina purpurea.
Elucidated the chemical structures of the isolated metabolites using spectroscopic analysis.
Screened the compounds for enzyme inhibition against histone deacetylase and DNA methyltransferase, as well as general cytotoxicity.
Psammaplin A, bisaprasin, and psammaplin F demonstrated potent inhibition of histone deacetylase alongside mild cytotoxicity.
Psammaplin A, bisaprasin, and psammaplin G exhibited potent inhibitory activity against DNA methyltransferase.
Structural analysis revealed rare oxalyl groups in psammaplins E and F, prompting a revised biogenetic pathway for the psammaplin class.

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Implication

In vitro study demonstrates dual epigenetic enzyme inhibition by bromotyrosine psammaplins from marine sponges, highlighting their potential as anticancer leads.

Cite This Study

Piña et al. (2003) studied this question.

synapsesocial.com/papers/6a7306b4f51de6dff732f27e https://doi.org/10.1021/jo034248t

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Implication

In vitro study demonstrates dual epigenetic enzyme inhibition by bromotyrosine psammaplins from marine sponges, highlighting their potential as anticancer leads.

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

Key Points

Discussion

Implication

Cite This Study

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

Key Points

Discussion

Implication

Cite This Study

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