Key result
Dexmedetomidine significantly reduced propofol-induced intravenous pain compared to dexamethasone, with a mean VAS score of 3.83 versus 4.53 (p<0.0001).
Why the study?
Does dexmedetomidine reduce propofol-induced intravenous pain compared to dexamethasone in patients undergoing general anesthesia?
RCT (n=60)
Triple-blind
Closed envelop method
No
Does dexmedetomidine reduce propofol-induced intravenous pain compared to dexamethasone in patients undergoing general anesthesia?
Dexmedetomidine provides superior attenuation of propofol-induced intravenous pain compared to dexamethasone, despite a higher incidence of transient bradycardia.
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Naik et al. (2022) conducted an RCT in Propofol-induced intravenous pain (n=60). Dexmedetomidine vs. Dexamethasone 0.1 mg/kg was evaluated on VAS pain score (p=<0.0001). Dexmedetomidine significantly reduced propofol-induced intravenous pain compared to dexamethasone, with a mean VAS score of 3.83 versus 4.53 (p<0.0001).
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