Key result
Dexmedetomidine-propofol provided better haemodynamic stability, reduced intraoperative propofol and fentanyl requirements, and prolonged postoperative analgesia compared to fentanyl-propofol.
Why the study?
Dexmedetomidine is gaining popularity for its sympatholytic, sedative, and haemodynamic stabilising properties without significant respiratory depression.
Does dexmedetomidine-propofol improve perioperative haemodynamics, reduce propofol requirement, and improve post-operative recovery compared to fentanyl-propofol in patients undergoing elective abdominal surgeries?
Population
60 ASA Grade I and II patients undergoing elective abdominal surgeries
Comparison
Dexmedetomidine-propofol vs fentanyl-propofol
Design
Prospective randomised double-blind study
Follow-up
24 h
Authors
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May support dexmedetomidine-propofol as alternative; leaves open larger trials before changing induction practice.
RCT (n=60)
Double-blind
randomised
Does dexmedetomidine-propofol improve perioperative haemodynamics, reduce propofol requirement, and improve post-operative recovery compared to fentanyl-propofol in patients undergoing elective abdominal surgeries?
Dexmedetomidine-propofol provides better haemodynamic stability, reduces anesthetic requirements, and improves recovery profiles compared to fentanyl-propofol in elective abdominal surgeries.
Jasmitha et al. (2022) conducted an RCT in Elective abdominal surgeries (n=60). Dexmedetomidine vs. Fentanyl was evaluated on Perioperative haemodynamics, propofol requirement, and post-operative recovery profile. Dexmedetomidine-propofol provided better haemodynamic stability, reduced intraoperative propofol and fentanyl requirements, and prolonged postoperative analgesia compared to fentanyl-propofol.
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