Key result
Combination treatment with clopidogrel and aspirin in STEMI patients yielded 0.062 additional QALYs and cost €1929 less than aspirin alone, demonstrating cost-effectiveness.
Why the study?
Is combination treatment with clopidogrel and aspirin cost-effective compared to aspirin alone in STEMI patients?
Is combination treatment with clopidogrel and aspirin cost-effective compared to aspirin alone in STEMI patients?
Clopidogrel combined with aspirin is a cost-effective strategy for STEMI patients in the Netherlands, dominating aspirin alone by providing more QALYs at lower costs.
Supports dual antiplatelet therapy as dominant in STEMI; extends RCT cost-effectiveness evidence to Dutch settings.
OBJECTIVE: This study assesses the costs and effects of combination treatment with clopidogrel and aspirin in comparison to aspirin alone in patients with an ST-segment elevation myocardial infarction (STEMI) in a Dutch setting. METHODS: A decision tree model is used to combine data from different sources about efficacy, epidemiology and costs. In the short-run, cost-effectiveness is based on efficacy data derived from the CLARITY trial. The cost-effectiveness of continued treatment is addressed by analysing which conditions need to be fulfilled to deem the strategy 'cost-effective', and discussing whether it is likely that it is. Estimates concerning the benefits of preventing events are derived from Swedish registries. Approximations of both direct and indirect costs are derived from the literature. Effects are expressed as life years gained and Quality Adjust Life Years (QALYs). Uncertainties are addressed by uni- and multivariate sensitivity analyses with and without taking account of the dependency between the separate ischaemic events. RESULTS: A treatment regimen similar to that of the CLARITY trial, including patients similar to those in the trial, is estimated to result in 0.05 additional life years and 0.062 additional quality adjusted life years for a cost that is euro1929 lower than aspirin therapy. Continuation of treatment outside the trial period is expected to result in ICERs of below euro20,000 per QALY as long as the real risk reduction of combination treatment is greater than 0.487% per year. CONCLUSION: The results indicate that clopidogrel therapy combined with aspirin, according to the regimen seen in CLARITY, and using data from Swedish registries to inform the model, is cost-effective. Sensitivity analyses suggest that the model is robust to a wide range of parameter estimates, including those based on data from Swedish registries. Continued treatment is very likely to be cost effective in light of all the indirect evidence.
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Thurston et al. (2010) studied ST-segment elevation myocardial infarction (STEMI). Clopidogrel and aspirin vs. Aspirin alone was evaluated on Cost-effectiveness (life years gained and QALYs). Combination treatment with clopidogrel and aspirin in STEMI patients yielded 0.062 additional QALYs and cost €1929 less than aspirin alone, demonstrating cost-effectiveness.
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