Population
Leukocytes and livers from normal and abetalipoproteinemic individuals
Comparison
Molecular analysis of the apolipoprotein B-100… vs Normal individuals (controls)
Design
Preclinical
Authors
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Suggests posttranslational apoB-100 defect in abetalipoproteinemia; leaves open validation in human studies before therapeutic pursuit.
The biochemical defect in abetalipoproteinemia is most consistent with a posttranslational defect in apoB-100 processing or secretion, accompanied by an up-regulation of apoB-100 mRNA.
Lackner et al. (1986) studied this question.
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