Key result
Estimated glomerular filtration rate was independently associated with all-cause mortality in Chinese patients with atrial fibrillation (HR 0.984 per 1 ml/min/1.73m2 increment).
Why the study?
The study was designed to evaluate the relationship between estimated glomerular filtration rate and 3-year clinical outcomes among Chinese patients with atrial fibrillation.
Does estimated glomerular filtration rate (eGFR) predict all-cause mortality in Chinese patients with atrial fibrillation?
Cohort (n=433)
No
Does estimated glomerular filtration rate (eGFR) predict all-cause mortality in Chinese patients with atrial fibrillation?
Hazard Ratio: 0.984 (95% CI 0.972–0.995)
p-value: p=0.006
Estimated glomerular filtration rate is an independent predictor of 3-year all-cause mortality in Chinese patients with atrial fibrillation, particularly those without valvular heart disease.
Supports eGFR for mortality risk stratification in Chinese AF; leaves open whether renal optimization alters outcomes.
BACKGROUND: Estimated glomerular filtration rate (eGFR) is a widely accepted indicator of renal function. The aim of this study was to evaluate the relationship between eGFR and 3-year clinical outcomes among Chinese patients with atrial fibrillation (AF). METHODS: We retrospectively studied 433 consecutive Chinese patients with AF (51.0% males, mean age 65.6 ± 13.2 years) between February 2013 and December 2017. Baseline clinical data were collected according to medical records. eGFR was calculated by MDRD equation for Chinese patients according to baseline age, sex and serum creatinine. The primary clinical outcome of interest was all-cause mortality. RESULTS: During a median follow-up period of 3.1 (0.5-4.5) years, 73 deaths (16.9%) were recorded. Multivariate Cox regression analyses indicated that eGFR was independently associated with all-cause death in total population [hazard ratio (HR) 0.984; 95% confidence interval (CI) 0.972-0.995, P = 0.006] and patients free of valvular heart diseases (VHDs) (HR 0.975; 95% CI 0.959-0.992, P = 0.003), but not with VHDs. A receiver operating characteristic (ROC) analysis revealed that reduced eGFR predicted all-cause mortality with areas under the ROC curve of 0.637 (95% CI 0.539-0.735, P = 0.004) in AF patients free of VHDs. CONCLUSIONS: eGFR is an independent predictor of 3-year all-cause mortality among Chinese patients with AF, especially among those patients free of VHDs.
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Wan et al. (2020) conducted a cohort in Atrial fibrillation (n=433). Estimated glomerular filtration rate (eGFR) was evaluated on All-cause mortality (HR 0.984, 95% CI 0.972-0.995, p=0.006). Estimated glomerular filtration rate was independently associated with all-cause mortality in Chinese patients with atrial fibrillation (HR 0.984 per 1 ml/min/1.73m2 increment).
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