Warfarin sodium therapy can be associated with severe skin and soft tissue necrosis requiring amputation.
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Warfarin may cause severe necrosis requiring multiple amputations; this case leaves open questions on incidence and prevention.
Skin and soft tissue necrosis is an uncommon but increasingly recognized complication of coumarin anticoagulant therapy. A patient is described with extensive involvement of all four extremities and the nose, requiring amputation of three extremities. The characteristic clinical features of the disorder are reviewed, with a discussion of the pathology, pathogenesis, and possible treatment modalities.
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Scandling et al. (1980) studied this question.
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