Key result
Resuming oral anticoagulation after OAC-induced skin necrosis yields no adverse effects in 7 reviewed cases.
Why the study?
Does resuming warfarin cause adverse effects in patients who previously developed warfarin skin necrosis?
Does resuming warfarin cause adverse effects in patients who previously developed warfarin skin necrosis?
Resuming warfarin in patients who developed warfarin-induced skin necrosis may be safe when prolonged anticoagulation is absolutely required, based on a small number of reported cases.
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May support cautious resumption when anticoagulation is essential; leaves open validation in prospective studies.
Jillella et al. (1996) conducted a review in Warfarin skin necrosis (n=58). Resuming oral anticoagulation was evaluated on Adverse effects upon resuming oral anticoagulation. Among 58 reviewed cases of skin necrosis attributed to oral anticoagulants, resuming oral anticoagulation in 7 patients resulted in no adverse effects.
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