Use of immunobiological drugs in the treatment of rheumatoid arthritis

In this article, we discuss the modern approaches to optimize rheumatoid arthritis therapy with biological antiinflammatory drugs using specific predictors. We describe the most important predictors such as body mass index, smoking, disease activity, concomitant therapy, and the presence of antibodies in predicting the effectiveness of biologicals. Also, we provide data on the ability to predict the response to a certain type of biological therapy on the basis of clinical variants of rheumatoid arthritis.