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September 5, 2025Proceedings of the National Academy of Sciences of Belarus Medical seriesOpen Access

The importance of liver detoxication function and the severity of endotoxinemia in the formation and implementation of central dysregulatory effects on body temperature

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Authors

FVF. I. VismontBelarusian State Medical University

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Implication

Observational analysis reveals liver detoxication and severity of endotoxinemia affect body temperature, indicating their role in dysregulatory processes.

Key Points

  • Insufficient liver detoxication results in altered body temperature regulation, highlighting its critical role.
  • Rats and rabbits show variable body temperature responses to E. coli endotoxin, indicating dependence on liver detoxification.
  • Changes in neurotransmitter and hormonal balances are linked to the liver's detoxification state and endotoxinemia severity.
  • Arginine levels decrease under endotoxinemia, affecting hypothalamic neuron properties and body temperature.

Cite This Study

F. I. Vismont (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfed50https://doi.org/10.29235/1814-6023-2025-22-3-205-219
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytokines and the hepatic acute phase response1997 · 724 citations
  2. 2Integration and Central Processing in Temperature Regulation1986 · 139 citations