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September 5, 2025Proceedings of the National Academy of Sciences of Belarus Medical seriesOpen Access

Characteristics of immune status in patients after liver transplantation with mesenchymal stem cell therapy

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Authors

СКС. В. КоротковVSV. V. SmolnikovaVGV. Yu. Grinevich

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Overview

Randomized study reveals MSC therapy improves immunophenotype and reduces acute rejection in liver transplant patients.

Key Points

  • The combination of MSC therapy with standard immunosuppression reduces acute rejection rates in liver transplant patients.
  • Patients receiving MSC therapy showed a 20% incidence of acute rejection compared to 33% in the control group.
  • Flow cytometry revealed an immunotolerant phenotype characterized by increased regulatory T cells in the MSC group.
  • Results indicate the potential for MSCs to enhance immunosuppression strategies in liver transplantation.

Cite This Study

Коротков et al. (2025) studied this question.

synapsesocial.com/papers/68bb46c36d6d5674bccfed56https://doi.org/10.29235/1814-6023-2025-22-3-220-231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up2024 · 16 citations
  2. 2Matrix metalloproteinases in liver injury, repair and fibrosis2015 · 502 citations
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  4. 4Allogeneic mesenchymal stem cells as induction therapy are safe and feasible in renal allografts: pilot results of a multicenter randomized controlled trial2018 · 108 citations
  5. 52016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection2016 · 653 citations