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Evaluate prostate cancer mortality trends in the United States from 1999 through 2020 and examine disparities across racial, ethnic, regional, and urbanization groups.

May 28, 2025Journal of Clinical Oncology

Prostate cancer mortality trends in the US (1999–2020).

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Evaluate prostate cancer mortality trends in the United States from 1999 through 2020 and examine disparities across racial, ethnic, regional, and urbanization groups.
Analyzed national death certificate data from the CDC WONDER database for adults aged 25 years and older between 1999 and 2020 (N=925,141 deaths).
Calculated age-adjusted mortality rates (AAMRs) per 100,000 stratified by race, ethnicity, US census region, and urbanization level.
Used Joinpoint regression to compute average annual percentage changes (AAPCs) with 95% confidence intervals.
Prostate cancer AAMRs declined from 25.8 per 100,000 (95% CI, 25.5–26.0) in 1999 to 17.9 per 100,000 (95% CI, 17.7–18.1) in 2020 (AAPC: -1.77%; 95% CI, -1.94 to -1.68; p < 0.000001).
Black men exhibited the highest overall AAMR (36.0 per 100,000; 95% CI, 35.8–36.2) but also the steepest decline (AAPC: -2.60%; 95% CI, -2.85 to -2.35; p < 0.000001), whereas the decline for American Indian/Alaska Native men was not significant (AAPC: -0.93%; 95% CI, -1.78 to 0.17; p = 0.083583).
Rural areas experienced higher mortality (AAMR: 21.2 per 100,000; 95% CI, 21.1–21.3) than urban areas (AAMR: 19.2 per 100,000), although both settings saw significant decreases (urban AAPC: -1.79%; rural AAPC: -1.61%).

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Implication

Population-based study reveals declining prostate cancer mortality across United States demographics, highlighting persistent racial and geographic disparities.

Cite This Study

Zia et al. (2025) studied this question.

synapsesocial.com/papers/6a73091342e8f550dbcd58d0 https://doi.org/10.1200/jco.2025.43.16_suppl.e23055

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Implication

Population-based study reveals declining prostate cancer mortality across United States demographics, highlighting persistent racial and geographic disparities.

Prostate cancer mortality trends in the US (1999–2020).

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Discussion

Implication

Cite This Study

Prostate cancer mortality trends in the US (1999–2020).

Key Points

Discussion

Implication

Cite This Study

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