Key result
Ischemia, rather than reperfusion, caused injury to cardiolipin, cytochrome c, and cytochrome oxidase in the isolated perfused rabbit heart.
Population
Isolated, perfused rabbit heart
Comparison
Reperfusion following ischemia vs Ischemia alone
Design
Preclinical
Authors
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Prioritizes ischemia over reperfusion for mitochondrial protection; leaves open human translation.
Mitochondrial injury involving cardiolipin, cytochrome c, and cytochrome oxidase in the isolated rabbit heart occurs primarily during ischemia rather than being exacerbated by reperfusion.
Lesnefsky et al. (2004) studied Ischemia and reperfusion injury. Ischemia vs. Reperfusion was evaluated on Injury to the distal electron chain involving cardiolipin, cytochrome c, and cytochrome oxidase. Ischemia, rather than reperfusion, caused injury to cardiolipin, cytochrome c, and cytochrome oxidase in the isolated perfused rabbit heart.
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