Key result
Aspirin effectiveness for the prevention of preeclampsia depends on chronobiological effect, compliance, gestational duration, and dosage, based on a review of 39 sources.
Why the study?
Aspirin prophylaxis for preeclampsia provides only a relative risk reduction and is often ineffective, while no effective treatments exist short of delivery.
Does aspirin prevent preeclampsia?
Does aspirin prevent preeclampsia?
The effectiveness of aspirin in preventing preeclampsia is variable and depends on factors such as dosage, gestational age, compliance, and chronobiology.
Clinicians should optimize chronobiology, compliance, initiation timing, and dose for aspirin in preeclampsia prevention; extends evidence on key efficacy modifiers.
Introduction. Preeclampsia is a hypertensive disorder of pregnancy that remains one of e leading causes of maternal and perinatal morbidity and mortality. The preventive strategy of prophylaxis with acetylsalicylic acid gives only a relative reduction in risk, and in a significant part of cases is ineffective. At the same time, the issue of preeclampsia prophylaxis is extremely relevant, since there are no effective methods for treating this condition, with the exception of the completion of gestation. Purpose of the study. Based on the scientific literature, to evaluate the effectiveness of aspirin in the prevention of preeclampsia and to determine the possible reasons for the lack of effectiveness of such prevention. Materials and methods. We conducted a search for scientific literature, as a result of which 39 sources were selected for the final scientific review (2010-2020). The PubMed, ResearchGate and Elibrary databases were used to search for scientific literature. Results and discussion. The article presents a literature review of the analysis of the effectiveness of aspirin for the prevention of preeclampsia over the past 5 years, describes the mechanism of action of aspirin, presents studies that confirm or refute the effectiveness of aspirin depending on the dosage and gestational age. Potential alternative agents for the prevention of preeclampsia in cases of aspirin ineffectiveness have been reviewed. Conclusion. Literature review data show that the effectiveness of aspirin for the prevention of preeclampsia depends on the chronobiological effect, compliance, gestational duration and dosage. It is necessary to continue research on the effectiveness of aspirin, and studies carried out on the Russian population will be of particular value for the Russian Federation.
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Kudryavceva et al. (2021) conducted a review in Preeclampsia. Aspirin was evaluated on Prevention of preeclampsia. Aspirin effectiveness for the prevention of preeclampsia depends on chronobiological effect, compliance, gestational duration, and dosage, based on a review of 39 sources.
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