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Characterize host inflammatory transcriptional signatures and immune responses to SARS-CoV-2 infection in the respiratory tract and circulating blood.

January 1, 2020Emerging Microbes & InfectionsOpen Access

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

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Authors

YXYong XiongAIDS United YLYuan LiuTongji University LCLiu CaoSun Yat-sen University

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Implication

Transcriptomic analysis reveals excessive cytokine release and apoptotic signaling in COVID-19 patients, highlighting molecular mechanisms underlying hyperinflammation and lymphopenia.

Key Points

Characterize host inflammatory transcriptional signatures and immune responses to SARS-CoV-2 infection in the respiratory tract and circulating blood.
Conducted transcriptome RNA sequencing on bronchoalveolar lavage fluid (BALF) specimens from COVID-19 patients.
Isolated and sequenced RNA from peripheral blood mononuclear cells (PBMCs) of COVID-19 patients to evaluate systemic immune alterations.
Identified marked inflammatory profiles driven by excessive cytokine and chemokine release, including elevated CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP-1B.
Demonstrated significant activation of apoptosis and the P53 signaling pathway in lymphocytes, pointing to a primary molecular driver of COVID-19-associated lymphopenia.

Cite This Study

Xiong et al. (2020) studied this question.

synapsesocial.com/papers/6a730af8000d38dc8b31e5e9 https://doi.org/10.1080/22221751.2020.1747363

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Implication

Transcriptomic analysis reveals excessive cytokine release and apoptotic signaling in COVID-19 patients, highlighting molecular mechanisms underlying hyperinflammation and lymphopenia.

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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