October 1, 1981Circulation ResearchOpen Access

Sequential QRS vector subtractions in acute myocardial infarction in humans. Time course and relationship to serial changes in serum CK-MB concentration.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the QRS difference vector (QRSMD) accurately predict infarct size compared to CK-MB analysis in patients with acute myocardial infarction?

Structured PICO

Does the QRS difference vector (QRSMD) accurately predict infarct size compared to CK-MB analysis in patients with acute myocardial infarction?

Population

14 patients admitted within 6 hours of the onset of symptoms of acute myocardial infarction (AMI)

Intervention

Hourly QRS subtractions on ECG signals obtained with dipolar leads using an automated recording system and computer analysis

Outcome

Time course of QRS difference vector (QRSMD) and its correlation with infarct size estimated from CK-MB analysissurrogate

While the QRS difference vector changes rapidly during early AMI and precedes CK-MB release, it is a poor predictor of total infarct size.

Lack of a preinfarction control ECG recording
Slowly developing changes in the ECG that were completed after the period of observation
Distortion of the QRS complex by injury currents associated with ST segment elevation

No takes yet. Share an insight, caveat, or question.

QRSMD should not guide infarct size assessment in AMI; leaves open its role as an early biomarker for prospective study.

Wikswo et al. (1981) studied this question.

View Full Paper

Ask AI

Bookmark