What question did this study set out to answer?

To evaluate cerebral lactate metabolism changes and identify alternative metabolic pathways in the hippocampus during diabetic progression.

November 1, 2019Molecular BrainOpen Access

Hyperpolarized 1-13Clactate flux increased in the hippocampal region in diabetic mice

View Full Paper

Ask AI

Bookmark

Authors

YCYoung‐Suk ChoiYonsei University JSJae Eun SongPalo Alto University JLJong Eun LeeUlsan College

Discussion

Member takes

Implication

Animal study demonstrates increased hippocampal lactate flux and activated ATP citrate lyase in diabetic mice, indicating an alternate pathway sustains energy when glucose transport drops.

Key Points

To evaluate cerebral lactate metabolism changes and identify alternative metabolic pathways in the hippocampus during diabetic progression.
Induced diabetes in mice via streptozotocin injection alongside a 60% high-fat diet for 6 months and compared them with control mice.
Measured in vivo brain metabolism using hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopy.
Quantified lactate amounts, GLUT1 mRNA levels, and phosphorylated ATP citrate lyase (Ser455) expression in isolated hippocampal and cortical tissues.
Diabetic mice exhibited an approximately 1.4-fold increase in the [1-13C]lactate/total 13C ratio specifically in the hippocampal region, despite whole-brain conversion remaining unchanged.
Hippocampal tissue displayed significantly decreased GLUT1 mRNA expression alongside elevated total lactate levels.
Phosphorylated ACLY (Ser455) was elevated in both the cortex and hippocampus, and the phosphorylated-to-total ACLY ratio positively correlated with hippocampal lactate content.

Cite This Study

Choi et al. (2019) studied this question.

synapsesocial.com/papers/6a730d3d8da1fde8aecd596b https://doi.org/10.1186/s13041-019-0505-9

View Full Paper

Ask AI

Bookmark

Implication

Animal study demonstrates increased hippocampal lactate flux and activated ATP citrate lyase in diabetic mice, indicating an alternate pathway sustains energy when glucose transport drops.

Hyperpolarized 1-13Clactate flux increased in the hippocampal region in diabetic mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyperpolarized 1-13Clactate flux increased in the hippocampal region in diabetic mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider