Key result
Normalized late-phase plaque echogenicity assessed by contrast-enhanced US was significantly greater in symptomatic carotid plaques compared to asymptomatic plaques (P=0.0005).
Why the study?
Does late-phase contrast-enhanced US detect differences in microbubble retention between symptomatic and asymptomatic carotid atherosclerotic plaques?
Cross-Sectional (n=37)
Does late-phase contrast-enhanced US detect differences in microbubble retention between symptomatic and asymptomatic carotid atherosclerotic plaques?
Absolute Event Rate: 0.39% vs 0.69%
p-value: p=.0005
Late-phase contrast-enhanced ultrasound can quantify microbubble retention in carotid plaques, demonstrating significant differences between symptomatic and asymptomatic plaques and showing promise for risk stratification.
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May support carotid plaque risk stratification; leaves open whether contrast-enhanced US improves outcomes over standard imaging.
Owen et al. (2010) conducted a cross-sectional in carotid atherosclerosis (n=37). Symptomatic carotid plaque vs. Asymptomatic carotid plaque was evaluated on Normalized late-phase plaque echogenicity (p=.0005). Normalized late-phase plaque echogenicity assessed by contrast-enhanced US was significantly greater in symptomatic carotid plaques compared to asymptomatic plaques (P=0.0005).
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