Necrosis of skin induced by coumarin in a patient deficient in protein S.

January 28, 1989BMJOpen Access

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Key Points

To describe the clinical course, endocrine evaluation, and recovery in a patient with protein S deficiency.
Monitored circulating plasma total thyroxine and thyroid stimulating hormone concentrations during clinical care.
Discontinued iodine supplementation and evaluated growth parameters and pituitary response via a thyrotrophin releasing hormone stimulation test at eight weeks.
Plasma total thyroxine and thyroid stimulating hormone concentrations returned to normal ranges with complete resolution of diarrhea and allergic symptoms.
Thyrotrophin releasing hormone response normalized by eight weeks alongside physical improvements of 1.5 kg weight gain and 2.0 cm linear growth.

P

Population

1 male patient deficient in protein S (based on title) with thyroid issues (based on abstract)

I

Intervention

Coumarin (from title); stopping iodine supplements (from abstract)

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This text appears to contain a mismatched title (coumarin-induced skin necrosis) and abstract (thyroid function recovery after stopping iodine).

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Grimaudo et al. (1989) studied this question.

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