What question did this study set out to answer?

Assess early and mid-term survival and causes of death following mitral valve replacement in patients aged 80 years and older.

May 1, 1997European Journal of Cardio-Thoracic SurgeryOpen Access

Survival and cause of death after mitral valve replacement in patients aged 80 years and over Collective results from the UK heart valve registry

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Why the study?

Does mitral valve replacement provide satisfactory survival in patients aged 80 years and over, and does valve type affect survival?

Population

96 patients aged 80 years and over from the UK Heart Valve Registry

Comparison

Mitral valve replacement with bioprosthetic or… vs Bioprosthetic versus mechanical valve implants

Design

Cohort

Follow-up

up to 5 years

Authors

GAGeorge AsimakopoulosVA San Diego Healthcare System

Discussion

Member takes

Implication

May support MVR consideration in selected octogenarians; leaves open valve type choice and need for randomized data.

Key Points

Assess early and mid-term survival and causes of death following mitral valve replacement in patients aged 80 years and older.
Retrospective analysis of data extracted from the UK Heart Valve Registry between January 1986 and December 1994.
Analyzed N=86 patients who underwent isolated mitral valve replacement (MVR) and N=10 who underwent combined MVR and aortic valve replacement (AVR).
Thirty-day mortality was 10.4% (9/86) for isolated MVR and 10% (1/10) for combined MVR and AVR, with 8 of 10 early deaths caused by cardiac conditions.
Actuarial survival in isolated MVR was 79.8% at 1 year, 64.1% at 3 years, and 40.7% at 5 years, with 19 of 28 late deaths attributable to non-cardiac causes.
No survival difference occurred between patients receiving bioprosthetic (57.2%, n=55) versus mechanical (42.8%, n=41) valve implants.

Structured PICO

Does mitral valve replacement provide satisfactory survival in patients aged 80 years and over, and does valve type affect survival?

Population

96 patients aged 80 years and over (86 isolated MVR, 10 combined MVR with AVR) from the UK Heart Valve Registry

Intervention

Mitral valve replacement (MVR) with bioprosthetic or mechanical valve

Comparator

Bioprosthetic versus mechanical valve implants

Outcome

30-day mortality and actuarial survival at 1, 3, and 5 yearshard clinical

Mitral valve replacement in octogenarians yields acceptable early mortality and moderate medium-term survival, with no significant difference between bioprosthetic and mechanical valves.

Cite This Study

George Asimakopoulos (1997) studied this question.

synapsesocial.com/papers/6a73135f542cb04b60cd5be0 https://doi.org/10.1016/s1010-7940(97)01206-2

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