Key result
Patient-specific patchy fibrosis in 3D atrial models caused rotors to stabilize and propagate slowly around fibrotic border zones, unlike the random meandering seen with uniform diffuse fibrosis.
Computational modeling demonstrates that AF rotors stabilize in the border zones of patchy fibrosis due to slow conduction, providing a mechanistic rationale for ablating around fibrotic regions.
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Should not change AF ablation practice; leaves open whether patient-specific fibrosis modeling guides therapy.
Morgan et al. (2016) studied Atrial fibrillation (n=3). Patient-specific patchy fibrosis vs. Uniform diffuse fibrosis was evaluated on Rotor stabilization and propagation dynamics. Patient-specific patchy fibrosis in 3D atrial models caused rotors to stabilize and propagate slowly around fibrotic border zones, unlike the random meandering seen with uniform diffuse fibrosis.
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