Key result
High residual fibrosis (>10%) and baseline atrial fibrosis were significant predictors of recurrent atrial fibrillation after catheter ablation (HR 3.2, P<0.01 and HR 2.2, P<0.01, respectively).
Why the study?
Does baseline atrial fibrosis and ablation-induced substrate modification predict recurrent atrial fibrillation better than pulmonary vein encirclement in patients undergoing catheter ablation?
Cohort (n=172)
Does baseline atrial fibrosis and ablation-induced substrate modification predict recurrent atrial fibrillation better than pulmonary vein encirclement in patients undergoing catheter ablation?
Hazard Ratio: 3.2
p-value: p=< 0.01
LGE-MRI demonstrates that baseline atrial fibrosis and ablation-induced substrate modification are better predictors of AF ablation success than complete pulmonary vein encirclement.
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May refine post-ablation risk stratification; leaves open whether fibrosis-targeted ablation outperforms PVI alone.
Akoum et al. (2015) conducted a cohort in Atrial fibrillation (n=172). High residual fibrosis (>10%) vs. Low residual fibrosis was evaluated on Recurrent atrial fibrillation (HR 3.2, p=< 0.01). High residual fibrosis (>10%) and baseline atrial fibrosis were significant predictors of recurrent atrial fibrillation after catheter ablation (HR 3.2, P<0.01 and HR 2.2, P<0.01, respectively).
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