Key result
The rapid breath-hold spiral TPM sequence yielded significantly higher edge sharpness (P=0.0014) but lower velocity-to-noise ratio (P<0.0001) compared to self-navigated TPM, with excellent velocity agreement (r>0.94).
Why the study?
Does a rapid breath-hold spiral TPM sequence using UNFOLD-ed SENSE accurately measure myocardial velocities compared to a self-navigated free-breathing technique in patients with aortic valve disease?
Does a rapid breath-hold spiral TPM sequence using UNFOLD-ed SENSE accurately measure myocardial velocities compared to a self-navigated free-breathing technique in patients with aortic valve disease?
A novel rapid breath-hold spiral TPM sequence using UNFOLD-ed SENSE enables accurate measurement of myocardial velocities in just eight heartbeats, offering a faster alternative to free-breathing techniques for clinical workflow.
Breath-hold spiral TPM may improve sharpness in cardiac TPM; leaves open routine adoption pending validation studies.
PURPOSE: To develop and validate a rapid breath-hold tissue phase mapping (TPM) sequence. MATERIALS AND METHODS: The sequence was based on an efficient uniform density spiral acquisition, combined with data acceleration. A novel acquisition and reconstruction strategy enabled combination of UNFOLD (2×) and SENSE (3×): UNFOLD-ed SENSE. The sequence was retrospectively cardiac-gated, and a graphics processing unit (GPU) was used for rapid "online" reconstruction. The optimal UNFOLD parameters for the data were calculated using an in silico model. The technique was validated on a 1.5T MR scanner in 15 patients with known aortic valve disease, against a respiratory self-navigated free-breathing TPM technique. Quantitative image quality measures (velocity-to-noise and edge sharpness) were made as well as calculation of longitudinal, radial, and tangential myocardial velocities in the left ventricle. RESULTS: The proposed breath-hold TPM data took eight heartbeats to acquire. The breath-hold TPM images had significantly higher edge sharpness (P = 0.0014) than the self-navigated TPM images, but with significantly lower velocity-to-noise ratio (P < 0.0001). There was excellent agreement (r > 0.94) in the longitudinal, radial, and tangential velocities between the self-navigated data and the proposed breath-hold TPM sequence. CONCLUSION: We demonstrate the feasibility of using spiral UNFOLD-ed SENSE to measure myocardial velocities using a rapid breath-hold spiral TPM sequence. This novel technique might enable accurate measurement of myocardial velocities, in a short scan time, which is especially important in a busy clinical workflow. J. MAGN. RESON. IMAGING 2016;44:1003-1009.
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Kowalik et al. (2016) studied Aortic valve disease (n=15). Rapid breath-hold spiral TPM sequence (spiral UNFOLD-ed SENSE) vs. Respiratory self-navigated free-breathing TPM technique was evaluated on Quantitative image quality measures (velocity-to-noise and edge sharpness) and myocardial velocities (p=0.0014). The rapid breath-hold spiral TPM sequence yielded significantly higher edge sharpness (P=0.0014) but lower velocity-to-noise ratio (P<0.0001) compared to self-navigated TPM, with excellent velocity agreement (r>0.94).
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