Key result
Human parechoviruses are a common cause of childhood infections, with severe forms like neonatal sepsis and central nervous system damage almost exclusively associated with parechovirus A type 3 (HPeV-A3).
Human parechovirus, particularly HPeV-A3, is an important emerging cause of severe infections including neonatal sepsis and CNS damage in young children, requiring increased awareness among pediatricians.
This article is a review of modern ideas about human parechovirus infection in children. At this time human parechoviruses are a common cause of infectious diseases in childhood with clinical presentation of acute gastroenteritis, upper respiratory tract pathology, fever, and rash. Severe forms damaging the central nervous system or the development of sepsis are possible in newborns and infants and are almost exclusively associated with parechovirus A type 3 (HPeV-A3). The infection is transmitted mainly via food and droplet routes. The main method of infection diagnosis is the detection of viral RNA by real-time PCR in cerebrospinal fluid, blood, and feces. No treatment for the parechovirus infection has been developed so far.
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Sabitova et al. (2023) conducted a review in Human parechovirus infection. Human parechovirus (HPeV) was evaluated. Human parechoviruses are a common cause of childhood infections, with severe forms like neonatal sepsis and central nervous system damage almost exclusively associated with parechovirus A type 3 (HPeV-A3).
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