Key result
High-intensity interval training increased ejection fraction and fractional shortening compared with endurance training and sedentary controls in mice.
Why the study?
HIIT shows beneficial cardiovascular effects and is more time-efficient than endurance exercise, but its molecular and functional cardiovascular benefits compared with endurance training required evaluation.
Does high-intensity interval training improve cardiac function and molecular markers in mice compared with endurance training or sedentary control?
Does high-intensity interval training improve cardiac function and molecular markers in mice compared with endurance training or sedentary control?
High-intensity interval training improves cardiac function and upregulates mitochondrial and antioxidative markers in a mouse model, suggesting it may be a viable alternative to traditional endurance training.
No immediate clinical implications from this animal model; leaves open whether HIIT outperforms endurance training in patients.
Human studies have shown high-intensity interval training (HIIT) has beneficial cardiovascular effects and is typically more time-efficient compared with traditional endurance exercise. The main goal of this study is to show the potential molecular and functional cardiovascular benefits of HIIT compared with endurance training (ET). Three groups of mice were used including sedentary-control, ET mice, and HIIT mice groups. Results indicated ejection fraction was increased in HIIT compared with ET while fractional shortening was increased in the HIIT group compared with both groups. Blood flow of the abdominal aorta was increased in both exercise groups compared with control. Increases in cross-sectional area and mitochondrial and antioxidative markers in HIIT compared with control were observed, along with several microRNAs. These findings indicate HIIT has specific cardiac-protective effects and may be a viable alternative to traditional ET as a cardiovascular preventative medicine intervention.
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Jeremić et al. (2019) studied this question. High-intensity interval training (HIIT) vs. Endurance training (ET) and sedentary-control was evaluated on Ejection fraction, fractional shortening, blood flow, and molecular markers. High-intensity interval training increased ejection fraction and fractional shortening compared with endurance training and sedentary controls in mice.
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