Why the study?
Does a 30-minute rate of protamine administration improve postoperative coagulation compared to a 5-minute rate in patients after coronary artery surgery?
Population
Patients after coronary artery surgery
Comparison
Calculated dose of protamine administered over… vs Calculated dose of protamine administered…
Design
Cohort
Follow-up
3 days
Authors
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Rapid protamine may prolong early postoperative coagulation after coronary surgery; hypothesis-generating for slower infusion in prospective trials.
Does a 30-minute rate of protamine administration improve postoperative coagulation compared to a 5-minute rate in patients after coronary artery surgery?
Administering protamine over 30 minutes without a bolus after coronary artery surgery prevents the prolonged coagulation observed 2 hours after rapid 5-minute administration.
Zaidan et al. (1986) studied this question.
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