Key result
Hyperbaric oxygenation (2 ata, 50 min) stimulates free radical oxidation in the brain, which is compensated by activation of enzyme protection mechanisms without depletion of antioxidant reserves.
Why the study?
The study was conducted to evaluate the effect of single and multiple therapeutic hyperbaric oxygenation exposures on lipid peroxidation and antioxidant defense enzymes in different brain structures during immediate and remote aftereffect periods.
Population
87 nonlinear white male rats weighing 180-230 grams
Comparison
1, 5, or 10 sessions of hyperbaric oxygenation vs remote aftereffect evaluation
Design
Prospective experimental study
Follow-up
Up to 10 days
Authors
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May inform short-term HBO safety in neuroprotection; hypothesis-generating for redox dynamics in cerebral hyperoxia.
Mild hyperbaric oxygenation induces a transient, compensable increase in free radical oxidation and antioxidant enzyme activity in the rat brain.
Bulgakova et al. (2023) studied this question. Hyperbaric oxygenation (HBO) was evaluated on Content of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase in brain structures. Hyperbaric oxygenation (2 ata, 50 min) stimulates free radical oxidation in the brain, which is compensated by activation of enzyme protection mechanisms without depletion of antioxidant reserves.
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