Key result
Growth hormone increased tibial growth and growth plate height in mice lacking the IGF-1 receptor in the growth plate compared to untreated mice.
Why the study?
Does growth hormone promote growth plate chondrogenesis and longitudinal bone growth independently of IGF-1 and IGF-2 in mice?
Does growth hormone promote growth plate chondrogenesis and longitudinal bone growth independently of IGF-1 and IGF-2 in mice?
Growth hormone can promote growth plate chondrogenesis and longitudinal bone growth directly at the growth plate, independent of local IGF-1 and IGF-2 effects.
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Supports direct GH effects on growth plate independent of IGF-1; hypothesis-generating for human growth disorders.
Wu et al. (2015) studied this question. Growth Hormone (GH) vs. Untreated mice was evaluated on Tibial growth and growth plate height. Growth hormone increased tibial growth and growth plate height in mice lacking the IGF-1 receptor in the growth plate compared to untreated mice.
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